Definition:
A short course of immune-suppressing medications given before or alongside enzymeA protein that helps the body carry out chemical reactions. replacement therapy, most often for CRIM-negativeA classification used in Pompe disease that describes whether a person's body produces any form of the GAA enzyme. People who are CRIM-positive produce some version of the enzyme, while those who are CRIM-negative do not. CRIM status is important because it can affect how the immune system responds to enzyme replacement therapy (ERT). patients, to prevent the immune system from attacking the replacement enzyme.
pronounced: ih-MYOON TOL-er-uhns in-DUK-shun
Related Terms:
antibodies (ERT-related), CRIM status, enzyme replacement therapy (ERT), immune response