TOP NEWS
Reports of Nexviazyme Shipment Delays
Pompe Alliance, Marshall’s Mountain, Grant’s Giants, Pompe Warrior Foundation, Ryan Colburn of the Pompe Community, and the AMDA are working together to help patients obtain clear and timely information regarding reports of NexviazymeA newer enzyme replacement therapy designed to improve delivery of the enzyme to muscle cells. shipment and release delays.
At this time, the delays being reported to our organizations involve some shipments of Nexviazyme. We have not received confirmation that LumizymeA form of enzyme replacement therapy used to treat Pompe disease by providing a lab-made version of the GAA enzyme. is currently affected, but patients using either treatment may wish to verify their upcoming shipment.
This appears to be a product-release and distribution timing issue — not evidence of a safety or quality problem with medication that has already been released. Patients should not panic or make treatment changes without speaking with their prescribing medical team.
In June 2026, the FDA issued a warning letter following a January inspection of a Sanofi facility in Waterford, Ireland. Sanofi has publicly stated that products released from the facility meet established quality and safety specifications. The FDA warning letter does not specifically identify Nexviazyme or Lumizyme as affected products, and we cannot independently confirm the precise cause of every current shipment delay.
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Acid Maltase Deficiency Association
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