Definition:
A classification used in Pompe diseaseA rare genetic disease in which the body cannot properly break down glycogen, leading to buildup that damages muscles and can affect breathing and, in some cases, the heart. that describes whether a person’s body produces any form of the GAA enzymeA protein that helps the body carry out chemical reactions.. People who are CRIM-positive produce some version of the enzyme, while those who are CRIM-negative do not. CRIM status is important because it can affect how the immune system responds to enzyme replacement therapy (ERT)A treatment that replaces the missing enzyme through IV infusion..
pronounced: krim STAY-tus
Related Terms:
antibodies (ERT-related), enzyme replacement therapy (ERT), GAA gene, immune response, infantile-onset Pompe disease (IOPD)